Sphingosine 1-phosphate receptor 5 (S1PR5)
Homo sapiens — UniProt Q9H228
Data last refreshed: (UniProt release unknown)
Key facts
Sphingosine 1-phosphate receptor 5 (S1PR5) is a protein from Homo sapiens identified by UniProt accession Q9H228, 398 residues long. MolForge cross-references it against 5 known binders and 159 disease associations.
- UniProt accession: Q9H228; gene symbol S1PR5.
- Organism: Homo sapiens.
- Length: 398 amino acids.
- Approved drugs acting on it (DrugCentral): Fingolimod, Siponimod, Ozanimod, Ponesimod and Etrasimod.
- Top disease associations (Open Targets): multiple sclerosis, relapsing-remitting multiple sclerosis and ulcerative colitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sphingosine 1-phosphate receptor 5 |
|---|---|
| UniProt accession | Q9H228 |
| Gene | S1PR5 |
| Organism | Homo sapiens |
| Length | 398 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (5)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (159)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- relapsing-remitting multiple sclerosis · score 0.59
- ulcerative colitis · score 0.55
- immune system disease · score 0.37
- type 2 diabetes mellitus · score 0.37
- Cognitive impairment · score 0.37
- primary progressive multiple sclerosis · score 0.32
- Crohn's disease · score 0.30
- chronic inflammatory demyelinating polyradiculoneuropathy · score 0.26
- ovarian cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H228-F1 | alphafold | PREDICTED | 77.74 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H228.
Amino-acid sequence (398 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target S1PR5?
DrugCentral lists 5 approved drugs whose mechanism of action is S1PR5: Fingolimod, Siponimod, Ozanimod, Ponesimod and Etrasimod.
Which diseases are associated with S1PR5?
The strongest Open Targets associations for S1PR5 are multiple sclerosis, relapsing-remitting multiple sclerosis, ulcerative colitis, immune system disease and type 2 diabetes mellitus.
How long is the S1PR5 protein?
The Homo sapiens S1PR5 protein (UniProt Q9H228) is 398 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H228 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H228 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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