Protein-serine O-palmitoleoyltransferase porcupine…

About Protein-serine O-palmitoleoyltransferase porcupine

Protein-serine O-palmitoleoyltransferase porcupine (PORCN) is a protein from Homo sapiens identified by UniProt accession Q9H237, 461 residues long. MolForge cross-references it against 0 known binders and 263 disease associations.

Target properties

Protein name	Protein-serine O-palmitoleoyltransferase porcupine
UniProt accession	Q9H237
Gene	PORCN
Organism	Homo sapiens
Length	461 residues
Molecular weight	—
EC numbers	—
Target class	—
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (263)

Diseases linked to this target (Open Targets).

focal dermal hypoplasia · score 0.84
genetic disorder · score 0.49
cancer · score 0.38
microphthalmia, isolated, with coloboma · score 0.37
Polydactyly · score 0.37
polydactyly · score 0.37
Global developmental delay · score 0.34
endometrial cancer · score 0.18
breast adenocarcinoma · score 0.18
forced expiratory volume · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9H237-F1	alphafold	PREDICTED	90.02	—

Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H237.

Amino-acid sequence (461 residues)

MATFSRQEFF QQLLQGCLLP TAQQGLDQIW LLLAICLACR LLWRLGLPSY LKHASTVAGG FFSLYHFFQL HMVWVVLLSL LCYLVLFLCR HSSHRGVFLS VTILIYLLMG EMHMVDTVTW HKMRGAQMIV AMKAVSLGFD LDRGEVGTVP SPVEFMGYLY FVGTIVFGPW ISFHSYLQAV QGRPLSCRWL QKVARSLALA LLCLVLSTCV GPYLFPYFIP LNGDRLLRNK KRKARGTMVR WLRAYESAVS FHFSNYFVGF LSEATATLAG AGFTEEKDHL EWDLTVSKPL NVELPRSMVE VVTSWNLPMS YWLNNYVFKN ALRLGTFSAV LVTYAASALL HGFSFHLAAV LLSLAFITYV EHVLRKRLAR ILSACVLSKR CPPDCSHQHR LGLGVRALNL LFGALAIFHL AYLGSLFDVD VDDTTEEQGY GMAYTVHKWS ELSWASHWVT FGCWIFYRLI G

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Protein-serine O-palmitoleoyltransferase porcupine (PORCN)