P2Y purinoceptor 12 (P2RY12)
Homo sapiens — UniProt Q9H244
Data last refreshed: (UniProt release unknown)
Key facts
P2Y purinoceptor 12 (P2RY12) is a protein from Homo sapiens identified by UniProt accession Q9H244, 342 residues long. MolForge cross-references it against 6 known binders and 391 disease associations.
- UniProt accession: Q9H244; gene symbol P2RY12.
- Organism: Homo sapiens.
- Length: 342 amino acids.
- Approved drugs acting on it (DrugCentral): Cangrelor, Ticagrelor, Clopidogrel, Prasugrel and Ticlopidine.
- Top disease associations (Open Targets): platelet-type bleeding disorder 8, P2Y12 defect and myocardial infarction.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | P2Y purinoceptor 12 |
|---|---|
| UniProt accession | Q9H244 |
| Gene | P2RY12 |
| Organism | Homo sapiens |
| Length | 342 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (5)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (391)
Diseases linked to this target (Open Targets).
- platelet-type bleeding disorder 8 · score 0.71
- P2Y12 defect · score 0.62
- myocardial infarction · score 0.61
- coronary artery disease · score 0.61
- acute coronary syndrome · score 0.61
- acute myocardial infarction · score 0.61
- stroke · score 0.60
- ST Elevation Myocardial Infarction · score 0.59
- peripheral arterial disease · score 0.59
- atrial fibrillation · score 0.59
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H244-F1 | alphafold | PREDICTED | 84.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H244.
Amino-acid sequence (342 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target P2RY12?
DrugCentral lists 5 approved drugs whose mechanism of action is P2RY12: Cangrelor, Ticagrelor, Clopidogrel, Prasugrel and Ticlopidine.
Which diseases are associated with P2RY12?
The strongest Open Targets associations for P2RY12 are platelet-type bleeding disorder 8, P2Y12 defect, myocardial infarction, coronary artery disease and acute coronary syndrome.
How long is the P2RY12 protein?
The Homo sapiens P2RY12 protein (UniProt Q9H244) is 342 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H244 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H244 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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