Voltage-gated inwardly rectifying potassium channel KCNH6 (KCNH6)
Homo sapiens — UniProt Q9H252
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-gated inwardly rectifying potassium channel KCNH6 (KCNH6) is a protein from Homo sapiens identified by UniProt accession Q9H252, 958 residues long. MolForge cross-references it against 0 known binders and 172 disease associations.
- UniProt accession: Q9H252; gene symbol KCNH6.
- Organism: Homo sapiens.
- Length: 958 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, Myasthenia gravis and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-gated inwardly rectifying potassium channel KCNH6 |
|---|---|
| UniProt accession | Q9H252 |
| Gene | KCNH6 |
| Organism | Homo sapiens |
| Length | 958 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (172)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- neurodegenerative disease · score 0.49
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- anterior ischemic optic neuropathy · score 0.37
- primary progressive multiple sclerosis · score 0.37
- transverse myelitis · score 0.37
- atrial flutter · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H252-F1 | alphafold | PREDICTED | 68.83 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H252.
Amino-acid sequence (958 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNH6?
The strongest Open Targets associations for KCNH6 are multiple sclerosis, Myasthenia gravis, neurodegenerative disease, small cell carcinoma and Muscle weakness.
How long is the KCNH6 protein?
The Homo sapiens KCNH6 protein (UniProt Q9H252) is 958 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H252 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H252 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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