Caspase recruitment domain-containing protein 9 (CARD9)
Homo sapiens — UniProt Q9H257
Data last refreshed: (UniProt release unknown)
Key facts
Caspase recruitment domain-containing protein 9 (CARD9) is a protein from Homo sapiens identified by UniProt accession Q9H257, 536 residues long. MolForge cross-references it against 0 known binders and 257 disease associations.
- UniProt accession: Q9H257; gene symbol CARD9.
- Organism: Homo sapiens.
- Length: 536 amino acids.
- Top disease associations (Open Targets): Chronic mucocutaneous candidosis, deep seated dermatophytosis and ulcerative colitis.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Caspase recruitment domain-containing protein 9 |
|---|---|
| UniProt accession | Q9H257 |
| Gene | CARD9 |
| Organism | Homo sapiens |
| Length | 536 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (257)
Diseases linked to this target (Open Targets).
- Chronic mucocutaneous candidosis · score 0.80
- deep seated dermatophytosis · score 0.37
- ulcerative colitis · score 0.32
- Crohn's disease · score 0.32
- inflammatory bowel disease · score 0.31
- ankylosing spondylitis · score 0.26
- psoriasis · score 0.25
- sclerosing cholangitis · score 0.22
- C-reactive protein measurement · score 0.21
- genetic disorder · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H257-F1 | alphafold | PREDICTED | 80.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H257.
Amino-acid sequence (536 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CARD9?
The strongest Open Targets associations for CARD9 are Chronic mucocutaneous candidosis, deep seated dermatophytosis, ulcerative colitis, Crohn's disease and inflammatory bowel disease.
How long is the CARD9 protein?
The Homo sapiens CARD9 protein (UniProt Q9H257) is 536 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H257 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H257 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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