Vacuolar protein sorting-associated protein 33B (VPS33B)
Homo sapiens — UniProt Q9H267
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein sorting-associated protein 33B (VPS33B) is a protein from Homo sapiens identified by UniProt accession Q9H267, 617 residues long. MolForge cross-references it against 0 known binders and 69 disease associations.
- UniProt accession: Q9H267; gene symbol VPS33B.
- Organism: Homo sapiens.
- Length: 617 amino acids.
- Top disease associations (Open Targets): Arthrogryposis - renal dysfunction - cholestasis, arthrogryposis-renal dysfunction-cholestasis syndrome and cholestasis, progressive familial intrahepatic, 12.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 33B |
|---|---|
| UniProt accession | Q9H267 |
| Gene | VPS33B |
| Organism | Homo sapiens |
| Length | 617 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (69)
Diseases linked to this target (Open Targets).
- Arthrogryposis - renal dysfunction - cholestasis · score 0.83
- arthrogryposis-renal dysfunction-cholestasis syndrome · score 0.60
- cholestasis, progressive familial intrahepatic, 12 · score 0.51
- genetic disorder · score 0.48
- arthrogryposis · score 0.47
- congenital anomaly of kidney and urinary tract · score 0.46
- COVID-19 · score 0.37
- tuberculosis · score 0.37
- multisite chronic pain · score 0.25
- Red cell distribution width · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H267-F1 | alphafold | PREDICTED | 91.45 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H267.
Amino-acid sequence (617 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS33B?
The strongest Open Targets associations for VPS33B are Arthrogryposis - renal dysfunction - cholestasis, arthrogryposis-renal dysfunction-cholestasis syndrome, cholestasis, progressive familial intrahepatic, 12, genetic disorder and arthrogryposis.
How long is the VPS33B protein?
The Homo sapiens VPS33B protein (UniProt Q9H267) is 617 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H267 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H267 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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