Vacuolar protein sorting-associated protein 16 homolog (VPS16)
Homo sapiens — UniProt Q9H269
Data last refreshed: (UniProt release unknown)
Key facts
Vacuolar protein sorting-associated protein 16 homolog (VPS16) is a protein from Homo sapiens identified by UniProt accession Q9H269, 839 residues long. MolForge cross-references it against 0 known binders and 99 disease associations.
- UniProt accession: Q9H269; gene symbol VPS16.
- Organism: Homo sapiens.
- Length: 839 amino acids.
- Top disease associations (Open Targets): Dystonia, neurodegenerative disease and COVID-19.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 16 homolog |
|---|---|
| UniProt accession | Q9H269 |
| Gene | VPS16 |
| Organism | Homo sapiens |
| Length | 839 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (99)
Diseases linked to this target (Open Targets).
- Dystonia · score 0.68
- neurodegenerative disease · score 0.53
- COVID-19 · score 0.37
- genetic disorder · score 0.19
- neutropenia · score 0.11
- Splenomegaly · score 0.11
- peripheral neuropathy · score 0.11
- Coarse facial features · score 0.11
- monocyte count · score 0.11
- myeloid white cell count · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H269-F1 | alphafold | PREDICTED | 91.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H269.
Amino-acid sequence (839 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with VPS16?
The strongest Open Targets associations for VPS16 are Dystonia, neurodegenerative disease, COVID-19, genetic disorder and neutropenia.
How long is the VPS16 protein?
The Homo sapiens VPS16 protein (UniProt Q9H269) is 839 amino acids long.
Browse: Targets: V · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H269 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H269 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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