SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3)
Homo sapiens — UniProt Q9H299
Data last refreshed: (UniProt release unknown)
Key facts
SH3 domain-binding glutamic acid-rich-like protein 3 (SH3BGRL3) is a protein from Homo sapiens identified by UniProt accession Q9H299, 93 residues long. MolForge cross-references it against 0 known binders and 57 disease associations.
- UniProt accession: Q9H299; gene symbol SH3BGRL3.
- Organism: Homo sapiens.
- Length: 93 amino acids.
- Top disease associations (Open Targets): brain measurement, monocyte count and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | SH3 domain-binding glutamic acid-rich-like protein 3 |
|---|---|
| UniProt accession | Q9H299 |
| Gene | SH3BGRL3 |
| Organism | Homo sapiens |
| Length | 93 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (57)
Diseases linked to this target (Open Targets).
- brain measurement · score 0.10
- monocyte count · score 0.08
- platelet count · score 0.08
- neoplasm · score 0.08
- acute myeloid leukemia · score 0.08
- eosinophil count · score 0.07
- asthma · score 0.06
- monocyte percentage of leukocytes · score 0.06
- hereditary palmoplantar keratoderma, Gamborg-Nielsen type · score 0.06
- hyperkeratosis lenticularis perstans · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H299-F1 | alphafold | PREDICTED | 96.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H299.
Amino-acid sequence (93 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SH3BGRL3?
The strongest Open Targets associations for SH3BGRL3 are brain measurement, monocyte count, platelet count, neoplasm and acute myeloid leukemia.
How long is the SH3BGRL3 protein?
The Homo sapiens SH3BGRL3 protein (UniProt Q9H299) is 93 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H299 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H299 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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