2-aminomuconic semialdehyde dehydrogenase (ALDH8A1)
Homo sapiens — UniProt Q9H2A2
Data last refreshed: (UniProt release unknown)
Key facts
2-aminomuconic semialdehyde dehydrogenase (ALDH8A1) is a protein from Homo sapiens identified by UniProt accession Q9H2A2, 487 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.
- UniProt accession: Q9H2A2; gene symbol ALDH8A1.
- Organism: Homo sapiens.
- Length: 487 amino acids.
- Top disease associations (Open Targets): mean corpuscular hemoglobin, mean corpuscular volume and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 2-aminomuconic semialdehyde dehydrogenase |
|---|---|
| UniProt accession | Q9H2A2 |
| Gene | ALDH8A1 |
| Organism | Homo sapiens |
| Length | 487 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (88)
Diseases linked to this target (Open Targets).
- mean corpuscular hemoglobin · score 0.52
- mean corpuscular volume · score 0.50
- erythrocyte count · score 0.44
- reticulocyte count · score 0.38
- platelet crit · score 0.37
- neurodegenerative disease · score 0.32
- lysosomal storage disease · score 0.32
- Alzheimer disease · score 0.32
- Parkinson disease · score 0.32
- multiple sclerosis · score 0.32
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2A2-F1 | alphafold | PREDICTED | 97.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2A2.
Amino-acid sequence (487 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ALDH8A1?
The strongest Open Targets associations for ALDH8A1 are mean corpuscular hemoglobin, mean corpuscular volume, erythrocyte count, reticulocyte count and platelet crit.
How long is the ALDH8A1 protein?
The Homo sapiens ALDH8A1 protein (UniProt Q9H2A2) is 487 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2A2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2A2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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