Synaptotagmin-4 (SYT4)
Homo sapiens — UniProt Q9H2B2
Data last refreshed: (UniProt release unknown)
Key facts
Synaptotagmin-4 (SYT4) is a protein from Homo sapiens identified by UniProt accession Q9H2B2, 425 residues long. MolForge cross-references it against 0 known binders and 84 disease associations.
- UniProt accession: Q9H2B2; gene symbol SYT4.
- Organism: Homo sapiens.
- Length: 425 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, physical activity measurement and body fat percentage.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Synaptotagmin-4 |
|---|---|
| UniProt accession | Q9H2B2 |
| Gene | SYT4 |
| Organism | Homo sapiens |
| Length | 425 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (84)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- physical activity measurement · score 0.27
- body fat percentage · score 0.24
- cortical surface area measurement · score 0.22
- body mass index · score 0.22
- waist-hip ratio · score 0.19
- high density lipoprotein cholesterol measurement · score 0.18
- brain measurement · score 0.18
- serum alanine aminotransferase measurement · score 0.15
- aspartate aminotransferase measurement · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2B2-F1 | alphafold | PREDICTED | 72.94 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2B2.
Amino-acid sequence (425 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SYT4?
The strongest Open Targets associations for SYT4 are neurodegenerative disease, physical activity measurement, body fat percentage, cortical surface area measurement and body mass index.
How long is the SYT4 protein?
The Homo sapiens SYT4 protein (UniProt Q9H2B2) is 425 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2B2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2B2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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