Gigaxonin (GAN)
Homo sapiens — UniProt Q9H2C0
Data last refreshed: (UniProt release unknown)
Key facts
Gigaxonin (GAN) is a protein from Homo sapiens identified by UniProt accession Q9H2C0, 597 residues long. MolForge cross-references it against 0 known binders and 323 disease associations.
- UniProt accession: Q9H2C0; gene symbol GAN.
- Organism: Homo sapiens.
- Length: 597 amino acids.
- Top disease associations (Open Targets): giant axonal neuropathy, genetic disorder and peripheral neuropathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Gigaxonin |
|---|---|
| UniProt accession | Q9H2C0 |
| Gene | GAN |
| Organism | Homo sapiens |
| Length | 597 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (323)
Diseases linked to this target (Open Targets).
- giant axonal neuropathy · score 0.76
- genetic disorder · score 0.51
- peripheral neuropathy · score 0.27
- Hypotonia · score 0.26
- Intellectual disability · score 0.26
- clear cell renal carcinoma · score 0.18
- Charcot-Marie-Tooth disease · score 0.16
- neuritic plaque measurement · score 0.11
- colonic neoplasm · score 0.10
- anal neoplasm · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2C0-F1 | alphafold | PREDICTED | 89.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2C0.
Amino-acid sequence (597 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GAN?
The strongest Open Targets associations for GAN are giant axonal neuropathy, genetic disorder, peripheral neuropathy, Hypotonia and Intellectual disability.
How long is the GAN protein?
The Homo sapiens GAN protein (UniProt Q9H2C0) is 597 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2C0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2C0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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