Semaphorin-6A (SEMA6A)
Homo sapiens — UniProt Q9H2E6
Data last refreshed: (UniProt release unknown)
Key facts
Semaphorin-6A (SEMA6A) is a protein from Homo sapiens identified by UniProt accession Q9H2E6, 1030 residues long. MolForge cross-references it against 0 known binders and 90 disease associations.
- UniProt accession: Q9H2E6; gene symbol SEMA6A.
- Organism: Homo sapiens.
- Length: 1030 amino acids.
- Top disease associations (Open Targets): cortical surface area measurement, neuroimaging measurement and neurodegenerative disease.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Semaphorin-6A |
|---|---|
| UniProt accession | Q9H2E6 |
| Gene | SEMA6A |
| Organism | Homo sapiens |
| Length | 1030 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (90)
Diseases linked to this target (Open Targets).
- cortical surface area measurement · score 0.42
- neuroimaging measurement · score 0.37
- neurodegenerative disease · score 0.37
- brain volume measurement · score 0.33
- brain measurement · score 0.33
- chronotype measurement · score 0.32
- delayed puberty, self-limited · score 0.27
- parapsoriasis · score 0.24
- thyroid gland adenocarcinoma · score 0.18
- protein measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2E6-F1 | alphafold | PREDICTED | 69.97 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2E6.
Amino-acid sequence (1030 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SEMA6A?
The strongest Open Targets associations for SEMA6A are cortical surface area measurement, neuroimaging measurement, neurodegenerative disease, brain volume measurement and brain measurement.
How long is the SEMA6A protein?
The Homo sapiens SEMA6A protein (UniProt Q9H2E6) is 1030 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2E6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2E6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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