3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7)
Homo sapiens — UniProt Q9H2F3
Data last refreshed: (UniProt release unknown)
Key facts
3 beta-hydroxysteroid dehydrogenase type 7 (HSD3B7) is a protein from Homo sapiens identified by UniProt accession Q9H2F3, 369 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q9H2F3; gene symbol HSD3B7.
- Organism: Homo sapiens.
- Length: 369 amino acids.
- Top disease associations (Open Targets): congenital bile acid synthesis defect 1, Congenital bile acid synthesis defect type 1 and mean corpuscular volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | 3 beta-hydroxysteroid dehydrogenase type 7 |
|---|---|
| UniProt accession | Q9H2F3 |
| Gene | HSD3B7 |
| Organism | Homo sapiens |
| Length | 369 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- congenital bile acid synthesis defect 1 · score 0.73
- Congenital bile acid synthesis defect type 1 · score 0.72
- mean corpuscular volume · score 0.32
- erythrocyte count · score 0.28
- mean corpuscular hemoglobin concentration · score 0.25
- vital capacity · score 0.25
- mean reticulocyte volume · score 0.23
- Immature Reticulocyte Fraction Measurement · score 0.23
- neuroticism measurement · score 0.20
- mean corpuscular hemoglobin · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2F3-F1 | alphafold | PREDICTED | 93.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2F3.
Amino-acid sequence (369 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HSD3B7?
The strongest Open Targets associations for HSD3B7 are congenital bile acid synthesis defect 1, Congenital bile acid synthesis defect type 1, mean corpuscular volume, erythrocyte count and mean corpuscular hemoglobin concentration.
How long is the HSD3B7 protein?
The Homo sapiens HSD3B7 protein (UniProt Q9H2F3) is 369 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2F3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2F3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.