Testis-specific Y-encoded-like protein 2 (TSPYL2)
Homo sapiens — UniProt Q9H2G4
Data last refreshed: (UniProt release unknown)
Key facts
Testis-specific Y-encoded-like protein 2 (TSPYL2) is a protein from Homo sapiens identified by UniProt accession Q9H2G4, 693 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.
- UniProt accession: Q9H2G4; gene symbol TSPYL2.
- Organism: Homo sapiens.
- Length: 693 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, attention deficit hyperactivity disorder and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Testis-specific Y-encoded-like protein 2 |
|---|---|
| UniProt accession | Q9H2G4 |
| Gene | TSPYL2 |
| Organism | Homo sapiens |
| Length | 693 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (98)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- attention deficit hyperactivity disorder · score 0.09
- neoplasm · score 0.09
- attention deficit-hyperactivity disorder 8 · score 0.09
- schizophrenia 15 · score 0.09
- cancer · score 0.09
- Tourette syndrome · score 0.07
- Phelan-McDermid syndrome · score 0.06
- pemphigus foliaceus · score 0.06
- X-linked non-syndromic intellectual disability · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2G4-F1 | alphafold | PREDICTED | 57.31 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2G4.
Amino-acid sequence (693 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TSPYL2?
The strongest Open Targets associations for TSPYL2 are neurodegenerative disease, attention deficit hyperactivity disorder, neoplasm, attention deficit-hyperactivity disorder 8 and schizophrenia 15.
How long is the TSPYL2 protein?
The Homo sapiens TSPYL2 protein (UniProt Q9H2G4) is 693 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2G4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2G4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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