Leucine-rich melanocyte differentiation-associated protein (LRMDA)
Homo sapiens — UniProt Q9H2I8
Data last refreshed: (UniProt release unknown)
Key facts
Leucine-rich melanocyte differentiation-associated protein (LRMDA) is a protein from Homo sapiens identified by UniProt accession Q9H2I8, 198 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.
- UniProt accession: Q9H2I8; gene symbol LRMDA.
- Organism: Homo sapiens.
- Length: 198 amino acids.
- Top disease associations (Open Targets): oculocutaneous albinism type 7, type 2 diabetes mellitus and heel bone mineral density.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Leucine-rich melanocyte differentiation-associated protein |
|---|---|
| UniProt accession | Q9H2I8 |
| Gene | LRMDA |
| Organism | Homo sapiens |
| Length | 198 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (102)
Diseases linked to this target (Open Targets).
- oculocutaneous albinism type 7 · score 0.61
- type 2 diabetes mellitus · score 0.49
- heel bone mineral density · score 0.45
- hematocrit · score 0.42
- hair shape measurement · score 0.42
- lean body mass · score 0.42
- appendicular lean mass · score 0.41
- FEV/FVC ratio · score 0.41
- hemoglobin measurement · score 0.41
- forced expiratory volume · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2I8-F1 | alphafold | PREDICTED | 78.02 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2I8.
Amino-acid sequence (198 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with LRMDA?
The strongest Open Targets associations for LRMDA are oculocutaneous albinism type 7, type 2 diabetes mellitus, heel bone mineral density, hematocrit and hair shape measurement.
How long is the LRMDA protein?
The Homo sapiens LRMDA protein (UniProt Q9H2I8) is 198 amino acids long.
Browse: Targets: L · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2I8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2I8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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