Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2)
Homo sapiens — UniProt Q9H2K2
Data last refreshed: (UniProt release unknown)
Key facts
Poly [ADP-ribose] polymerase tankyrase-2 (TNKS2) is a protein from Homo sapiens identified by UniProt accession Q9H2K2, 1166 residues long. MolForge cross-references it against 5 known binders and 93 disease associations.
- UniProt accession: Q9H2K2; gene symbol TNKS2.
- Organism: Homo sapiens.
- Length: 1166 amino acids.
- Approved drugs acting on it (DrugCentral): Rucaparib.
- Top disease associations (Open Targets): sex hormone-binding globulin measurement, alkaline phosphatase measurement and testosterone measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Poly [ADP-ribose] polymerase tankyrase-2 |
|---|---|
| UniProt accession | Q9H2K2 |
| Gene | TNKS2 |
| Organism | Homo sapiens |
| Length | 1166 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). Approved drug exists
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Approved drugs acting on this target (1)
Approved drugs whose DrugCentral mechanism of action is this protein, most potent first.
Disease associations (93)
Diseases linked to this target (Open Targets).
- sex hormone-binding globulin measurement · score 0.46
- alkaline phosphatase measurement · score 0.42
- testosterone measurement · score 0.38
- neutrophil count · score 0.38
- cancer · score 0.37
- leukocyte count · score 0.37
- urate measurement · score 0.33
- PHF-tau measurement · score 0.27
- liver volume · score 0.27
- fat body mass · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2K2-F1 | alphafold | PREDICTED | 83.84 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2K2.
Amino-acid sequence (1166 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which approved drugs target TNKS2?
DrugCentral lists 1 approved drug whose mechanism of action is TNKS2: Rucaparib.
Which diseases are associated with TNKS2?
The strongest Open Targets associations for TNKS2 are sex hormone-binding globulin measurement, alkaline phosphatase measurement, testosterone measurement, neutrophil count and cancer.
How long is the TNKS2 protein?
The Homo sapiens TNKS2 protein (UniProt Q9H2K2) is 1166 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2K2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2K2 — predicted 3D structure (CC BY 4.0)
- DrugCentral — approved drugs and mechanism-of-action links (CC BY-SA 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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