Transmembrane protein 60 (TMEM60)
Homo sapiens — UniProt Q9H2L4
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protein 60 (TMEM60) is a protein from Homo sapiens identified by UniProt accession Q9H2L4, 133 residues long. MolForge cross-references it against 0 known binders and 113 disease associations.
- UniProt accession: Q9H2L4; gene symbol TMEM60.
- Organism: Homo sapiens.
- Length: 133 amino acids.
- Top disease associations (Open Targets): serum urea measurement, sex hormone-binding globulin measurement and calcium measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protein 60 |
|---|---|
| UniProt accession | Q9H2L4 |
| Gene | TMEM60 |
| Organism | Homo sapiens |
| Length | 133 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (113)
Diseases linked to this target (Open Targets).
- serum urea measurement · score 0.29
- sex hormone-binding globulin measurement · score 0.28
- calcium measurement · score 0.27
- creatinine measurement · score 0.27
- BMI-adjusted waist-hip ratio · score 0.25
- glomerular filtration rate · score 0.23
- high density lipoprotein cholesterol measurement · score 0.23
- metabolite measurement · score 0.22
- systolic blood pressure · score 0.21
- hypertension · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2L4-F1 | alphafold | PREDICTED | 77.39 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2L4.
Amino-acid sequence (133 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMEM60?
The strongest Open Targets associations for TMEM60 are serum urea measurement, sex hormone-binding globulin measurement, calcium measurement, creatinine measurement and BMI-adjusted waist-hip ratio.
How long is the TMEM60 protein?
The Homo sapiens TMEM60 protein (UniProt Q9H2L4) is 133 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2L4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2L4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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