S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2)
Homo sapiens — UniProt Q9H2M3
Data last refreshed: (UniProt release unknown)
Key facts
S-methylmethionine--homocysteine S-methyltransferase BHMT2 (BHMT2) is a protein from Homo sapiens identified by UniProt accession Q9H2M3, 363 residues long. MolForge cross-references it against 0 known binders and 68 disease associations.
- UniProt accession: Q9H2M3; gene symbol BHMT2.
- Organism: Homo sapiens.
- Length: 363 amino acids.
- Top disease associations (Open Targets): homocystinuria, neurodegenerative disease and unipolar depression.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | S-methylmethionine--homocysteine S-methyltransferase BHMT2 |
|---|---|
| UniProt accession | Q9H2M3 |
| Gene | BHMT2 |
| Organism | Homo sapiens |
| Length | 363 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (68)
Diseases linked to this target (Open Targets).
- homocystinuria · score 0.51
- neurodegenerative disease · score 0.49
- unipolar depression · score 0.46
- serum metabolite measurement · score 0.42
- dimethylglycine measurement · score 0.29
- xerostomia · score 0.26
- protein measurement · score 0.21
- urinary metabolite measurement · score 0.20
- selenium measurement · score 0.20
- salivary metabolite measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2M3-F1 | alphafold | PREDICTED | 95.62 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2M3.
Amino-acid sequence (363 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with BHMT2?
The strongest Open Targets associations for BHMT2 are homocystinuria, neurodegenerative disease, unipolar depression, serum metabolite measurement and dimethylglycine measurement.
How long is the BHMT2 protein?
The Homo sapiens BHMT2 protein (UniProt Q9H2M3) is 363 amino acids long.
Browse: Targets: B · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2M3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2M3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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