Activity-dependent neuroprotector homeobox protein (ADNP)
Homo sapiens — UniProt Q9H2P0
Data last refreshed: (UniProt release unknown)
Key facts
Activity-dependent neuroprotector homeobox protein (ADNP) is a protein from Homo sapiens identified by UniProt accession Q9H2P0, 1102 residues long. MolForge cross-references it against 0 known binders and 157 disease associations.
- UniProt accession: Q9H2P0; gene symbol ADNP.
- Organism: Homo sapiens.
- Length: 1102 amino acids.
- Top disease associations (Open Targets): ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder, ADNP-related multiple congenital anomalies-intellectual disability-autism spectrum disorder and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Activity-dependent neuroprotector homeobox protein |
|---|---|
| UniProt accession | Q9H2P0 |
| Gene | ADNP |
| Organism | Homo sapiens |
| Length | 1102 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (157)
Diseases linked to this target (Open Targets).
- ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder · score 0.78
- ADNP-related multiple congenital anomalies-intellectual disability-autism spectrum disorder · score 0.75
- genetic disorder · score 0.54
- Intellectual disability · score 0.51
- neurodegenerative disease · score 0.49
- sex hormone-binding globulin measurement · score 0.35
- Global developmental delay · score 0.35
- Neurodevelopmental disorder · score 0.34
- Seizure · score 0.29
- autism spectrum disorder · score 0.28
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2P0-F1 | alphafold | PREDICTED | 56.20 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2P0.
Amino-acid sequence (1102 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADNP?
The strongest Open Targets associations for ADNP are ADNP-related multiple congenital anomalies - intellectual disability - autism spectrum disorder, ADNP-related multiple congenital anomalies-intellectual disability-autism spectrum disorder, genetic disorder, Intellectual disability and neurodegenerative disease.
How long is the ADNP protein?
The Homo sapiens ADNP protein (UniProt Q9H2P0) is 1102 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2P0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2P0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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