RING finger protein 39 (RNF39)
Homo sapiens — UniProt Q9H2S5
Data last refreshed: (UniProt release unknown)
Key facts
RING finger protein 39 (RNF39) is a protein from Homo sapiens identified by UniProt accession Q9H2S5, 420 residues long. MolForge cross-references it against 0 known binders and 63 disease associations.
- UniProt accession: Q9H2S5; gene symbol RNF39.
- Organism: Homo sapiens.
- Length: 420 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, Takayasu arteritis and hepatocellular carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | RING finger protein 39 |
|---|---|
| UniProt accession | Q9H2S5 |
| Gene | RNF39 |
| Organism | Homo sapiens |
| Length | 420 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (63)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.28
- Takayasu arteritis · score 0.27
- hepatocellular carcinoma · score 0.17
- Graves disease · score 0.13
- asthma · score 0.12
- HIV-1 infection · score 0.11
- Vitiligo · score 0.06
- interleukin-1 beta measurement · score 0.05
- late-onset myasthenia gravis · score 0.05
- severe cutaneous adverse reaction · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2S5-F1 | alphafold | PREDICTED | 66.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2S5.
Amino-acid sequence (420 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with RNF39?
The strongest Open Targets associations for RNF39 are neurodegenerative disease, Takayasu arteritis, hepatocellular carcinoma, Graves disease and asthma.
How long is the RNF39 protein?
The Homo sapiens RNF39 protein (UniProt Q9H2S5) is 420 amino acids long.
Browse: Targets: R · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2S5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2S5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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