Zinc finger protein Eos (IKZF4)
Homo sapiens — UniProt Q9H2S9
Data last refreshed: (UniProt release unknown)
Key facts
Zinc finger protein Eos (IKZF4) is a protein from Homo sapiens identified by UniProt accession Q9H2S9, 585 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: Q9H2S9; gene symbol IKZF4.
- Organism: Homo sapiens.
- Length: 585 amino acids.
- Top disease associations (Open Targets): Blackfan-Diamond anemia, FEV/FVC ratio and eosinophil count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Zinc finger protein Eos |
|---|---|
| UniProt accession | Q9H2S9 |
| Gene | IKZF4 |
| Organism | Homo sapiens |
| Length | 585 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- Blackfan-Diamond anemia · score 0.33
- FEV/FVC ratio · score 0.23
- eosinophil count · score 0.22
- Vitiligo · score 0.20
- type 1 diabetes mellitus · score 0.20
- heel bone mineral density · score 0.19
- asthma · score 0.19
- self reported educational attainment · score 0.17
- IGF-1 measurement · score 0.16
- autoimmune disease · score 0.16
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2S9-F1 | alphafold | PREDICTED | 48.95 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2S9.
Amino-acid sequence (585 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IKZF4?
The strongest Open Targets associations for IKZF4 are Blackfan-Diamond anemia, FEV/FVC ratio, eosinophil count, Vitiligo and type 1 diabetes mellitus.
How long is the IKZF4 protein?
The Homo sapiens IKZF4 protein (UniProt Q9H2S9) is 585 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2S9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2S9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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