ATP-dependent DNA/RNA helicase DHX36 (DHX36)
Homo sapiens — UniProt Q9H2U1
Data last refreshed: (UniProt release unknown)
Key facts
ATP-dependent DNA/RNA helicase DHX36 (DHX36) is a protein from Homo sapiens identified by UniProt accession Q9H2U1, 1008 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.
- UniProt accession: Q9H2U1; gene symbol DHX36.
- Organism: Homo sapiens.
- Length: 1008 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body mass index and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | ATP-dependent DNA/RNA helicase DHX36 |
|---|---|
| UniProt accession | Q9H2U1 |
| Gene | DHX36 |
| Organism | Homo sapiens |
| Length | 1008 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (70)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- body mass index · score 0.45
- lean body mass · score 0.39
- fat body mass · score 0.35
- coronary artery disease · score 0.32
- high density lipoprotein cholesterol measurement · score 0.25
- cystatin C measurement · score 0.24
- apolipoprotein A 1 measurement · score 0.24
- myocardial infarction · score 0.24
- whole body water mass · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2U1-F1 | alphafold | PREDICTED | 82.44 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2U1.
Amino-acid sequence (1008 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DHX36?
The strongest Open Targets associations for DHX36 are neurodegenerative disease, body mass index, lean body mass, fat body mass and coronary artery disease.
How long is the DHX36 protein?
The Homo sapiens DHX36 protein (UniProt Q9H2U1) is 1008 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2U1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2U1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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