Inorganic pyrophosphatase 2, mitochondrial (PPA2)
Homo sapiens — UniProt Q9H2U2
Data last refreshed: (UniProt release unknown)
Key facts
Inorganic pyrophosphatase 2, mitochondrial (PPA2) is a protein from Homo sapiens identified by UniProt accession Q9H2U2, 334 residues long. MolForge cross-references it against 0 known binders and 147 disease associations.
- UniProt accession: Q9H2U2; gene symbol PPA2.
- Organism: Homo sapiens.
- Length: 334 amino acids.
- Top disease associations (Open Targets): sudden cardiac arrest, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Inorganic pyrophosphatase 2, mitochondrial |
|---|---|
| UniProt accession | Q9H2U2 |
| Gene | PPA2 |
| Organism | Homo sapiens |
| Length | 334 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (147)
Diseases linked to this target (Open Targets).
- sudden cardiac arrest · score 0.77
- neurodegenerative disease · score 0.53
- genetic disorder · score 0.50
- calcium measurement · score 0.34
- total blood protein measurement · score 0.34
- self reported educational attainment · score 0.32
- lymphocyte count · score 0.32
- mean corpuscular volume · score 0.32
- mean corpuscular hemoglobin · score 0.31
- body height · score 0.30
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2U2-F1 | alphafold | PREDICTED | 86.57 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2U2.
Amino-acid sequence (334 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PPA2?
The strongest Open Targets associations for PPA2 are sudden cardiac arrest, neurodegenerative disease, genetic disorder, calcium measurement and total blood protein measurement.
How long is the PPA2 protein?
The Homo sapiens PPA2 protein (UniProt Q9H2U2) is 334 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2U2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2U2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.