Disintegrin and metalloproteinase domain-containing protein 7 (ADAM7)
Homo sapiens — UniProt Q9H2U9
Data last refreshed: (UniProt release unknown)
Key facts
Disintegrin and metalloproteinase domain-containing protein 7 (ADAM7) is a protein from Homo sapiens identified by UniProt accession Q9H2U9, 754 residues long. MolForge cross-references it against 0 known binders and 80 disease associations.
- UniProt accession: Q9H2U9; gene symbol ADAM7.
- Organism: Homo sapiens.
- Length: 754 amino acids.
- Top disease associations (Open Targets): skin vascular disease, mathematical ability and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Disintegrin and metalloproteinase domain-containing protein 7 |
|---|---|
| UniProt accession | Q9H2U9 |
| Gene | ADAM7 |
| Organism | Homo sapiens |
| Length | 754 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (80)
Diseases linked to this target (Open Targets).
- skin vascular disease · score 0.16
- mathematical ability · score 0.15
- monocyte count · score 0.10
- azoospermia · score 0.08
- male infertility with teratozoospermia due to single gene mutation · score 0.07
- congenital bilateral absence of vas deferens · score 0.06
- spermatogenic failure 65 · score 0.05
- spermatogenic failure 56 · score 0.05
- spermatogenic failure 72 · score 0.05
- spermatogenic failure 63 · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2U9-F1 | alphafold | PREDICTED | 74.86 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2U9.
Amino-acid sequence (754 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAM7?
The strongest Open Targets associations for ADAM7 are skin vascular disease, mathematical ability, monocyte count, azoospermia and male infertility with teratozoospermia due to single gene mutation.
How long is the ADAM7 protein?
The Homo sapiens ADAM7 protein (UniProt Q9H2U9) is 754 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2U9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2U9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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