Protein spinster homolog 1 (SPNS1)
Homo sapiens — UniProt Q9H2V7
Data last refreshed: (UniProt release unknown)
Key facts
Protein spinster homolog 1 (SPNS1) is a protein from Homo sapiens identified by UniProt accession Q9H2V7, 528 residues long. MolForge cross-references it against 0 known binders and 51 disease associations.
- UniProt accession: Q9H2V7; gene symbol SPNS1.
- Organism: Homo sapiens.
- Length: 528 amino acids.
- Top disease associations (Open Targets): total blood protein measurement, lymphocyte count and platelet count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Protein spinster homolog 1 |
|---|---|
| UniProt accession | Q9H2V7 |
| Gene | SPNS1 |
| Organism | Homo sapiens |
| Length | 528 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (51)
Diseases linked to this target (Open Targets).
- total blood protein measurement · score 0.18
- lymphocyte count · score 0.16
- platelet count · score 0.15
- serum non-albumin protein measurement · score 0.15
- hemoglobin measurement · score 0.11
- mean reticulocyte volume · score 0.08
- electrocardiography · score 0.08
- health study participation · score 0.07
- risk-taking behaviour · score 0.06
- BMI-adjusted hip circumference · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2V7-F1 | alphafold | PREDICTED | 84.41 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2V7.
Amino-acid sequence (528 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SPNS1?
The strongest Open Targets associations for SPNS1 are total blood protein measurement, lymphocyte count, platelet count, serum non-albumin protein measurement and hemoglobin measurement.
How long is the SPNS1 protein?
The Homo sapiens SPNS1 protein (UniProt Q9H2V7) is 528 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2V7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2V7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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