Membrane-spanning 4-domains subfamily A member 6A (MS4A6A)
Homo sapiens — UniProt Q9H2W1
Data last refreshed: (UniProt release unknown)
Key facts
Membrane-spanning 4-domains subfamily A member 6A (MS4A6A) is a protein from Homo sapiens identified by UniProt accession Q9H2W1, 248 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.
- UniProt accession: Q9H2W1; gene symbol MS4A6A.
- Organism: Homo sapiens.
- Length: 248 amino acids.
- Top disease associations (Open Targets): heel bone mineral density, soluble triggering receptor expressed on myeloid cells 2 measurement and total blood protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Membrane-spanning 4-domains subfamily A member 6A |
|---|---|
| UniProt accession | Q9H2W1 |
| Gene | MS4A6A |
| Organism | Homo sapiens |
| Length | 248 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (87)
Diseases linked to this target (Open Targets).
- heel bone mineral density · score 0.39
- soluble triggering receptor expressed on myeloid cells 2 measurement · score 0.32
- total blood protein measurement · score 0.29
- fibrinogen measurement · score 0.26
- blood protein measurement · score 0.25
- lymphocyte percentage of leukocytes · score 0.25
- C-reactive protein measurement · score 0.24
- neutrophil count · score 0.23
- lactadherin measurement · score 0.22
- Alzheimer disease · score 0.22
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2W1-F1 | alphafold | PREDICTED | 74.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2W1.
Amino-acid sequence (248 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MS4A6A?
The strongest Open Targets associations for MS4A6A are heel bone mineral density, soluble triggering receptor expressed on myeloid cells 2 measurement, total blood protein measurement, fibrinogen measurement and blood protein measurement.
How long is the MS4A6A protein?
The Homo sapiens MS4A6A protein (UniProt Q9H2W1) is 248 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2W1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2W1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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