Large ribosomal subunit protein mL46 (MRPL46)
Homo sapiens — UniProt Q9H2W6
Data last refreshed: (UniProt release unknown)
Key facts
Large ribosomal subunit protein mL46 (MRPL46) is a protein from Homo sapiens identified by UniProt accession Q9H2W6, 279 residues long. MolForge cross-references it against 0 known binders and 20 disease associations.
- UniProt accession: Q9H2W6; gene symbol MRPL46.
- Organism: Homo sapiens.
- Length: 279 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, major depressive disorder and protein measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Large ribosomal subunit protein mL46 |
|---|---|
| UniProt accession | Q9H2W6 |
| Gene | MRPL46 |
| Organism | Homo sapiens |
| Length | 279 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (20)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.32
- major depressive disorder · score 0.14
- protein measurement · score 0.12
- prostate cancer · score 0.11
- Familial prostate cancer · score 0.11
- prostate carcinoma · score 0.11
- age at menarche · score 0.04
- age at first facial hair · score 0.04
- unipolar depression · score 0.03
- gut microbiome measurement · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2W6-F1 | alphafold | PREDICTED | 79.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2W6.
Amino-acid sequence (279 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MRPL46?
The strongest Open Targets associations for MRPL46 are neurodegenerative disease, major depressive disorder, protein measurement, prostate cancer and Familial prostate cancer.
How long is the MRPL46 protein?
The Homo sapiens MRPL46 protein (UniProt Q9H2W6) is 279 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2W6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2W6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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