Homeodomain-interacting protein kinase 2 (HIPK2)
Homo sapiens — UniProt Q9H2X6
Data last refreshed: (UniProt release unknown)
Key facts
Homeodomain-interacting protein kinase 2 (HIPK2) is a protein from Homo sapiens identified by UniProt accession Q9H2X6, 1198 residues long. MolForge cross-references it against 10 known binders and 260 disease associations.
- UniProt accession: Q9H2X6; gene symbol HIPK2.
- Organism: Homo sapiens.
- Length: 1198 amino acids.
- Top disease associations (Open Targets): systolic blood pressure, diastolic blood pressure and pulse pressure measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeodomain-interacting protein kinase 2 |
|---|---|
| UniProt accession | Q9H2X6 |
| Gene | HIPK2 |
| Organism | Homo sapiens |
| Length | 1198 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (260)
Diseases linked to this target (Open Targets).
- systolic blood pressure · score 0.48
- diastolic blood pressure · score 0.39
- pulse pressure measurement · score 0.39
- mean arterial pressure · score 0.38
- cardiovascular disease · score 0.38
- hypertension · score 0.36
- neurodegenerative disease · score 0.35
- Agents acting on the renin-angiotensin system use measurement · score 0.31
- breast adenocarcinoma · score 0.26
- PHF-tau measurement · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2X6-F1 | alphafold | PREDICTED | 52.40 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2X6.
Amino-acid sequence (1198 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HIPK2?
The strongest Open Targets associations for HIPK2 are systolic blood pressure, diastolic blood pressure, pulse pressure measurement, mean arterial pressure and cardiovascular disease.
How long is the HIPK2 protein?
The Homo sapiens HIPK2 protein (UniProt Q9H2X6) is 1198 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2X6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2X6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.