Interferon alpha-inducible protein 27-like protein 2 (IFI27L2)
Homo sapiens — UniProt Q9H2X8
Data last refreshed: (UniProt release unknown)
Key facts
Interferon alpha-inducible protein 27-like protein 2 (IFI27L2) is a protein from Homo sapiens identified by UniProt accession Q9H2X8, 130 residues long. MolForge cross-references it against 0 known binders and 60 disease associations.
- UniProt accession: Q9H2X8; gene symbol IFI27L2.
- Organism: Homo sapiens.
- Length: 130 amino acids.
- Top disease associations (Open Targets): metabolite measurement, retinitis pigmentosa and Familial exudative vitreoretinopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Interferon alpha-inducible protein 27-like protein 2 |
|---|---|
| UniProt accession | Q9H2X8 |
| Gene | IFI27L2 |
| Organism | Homo sapiens |
| Length | 130 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (60)
Diseases linked to this target (Open Targets).
- metabolite measurement · score 0.06
- retinitis pigmentosa · score 0.06
- Familial exudative vitreoretinopathy · score 0.06
- snowflake vitreoretinal degeneration · score 0.04
- Coats disease · score 0.04
- Megalocornea · score 0.04
- megalocornea · score 0.04
- asthma, nasal polyps, and aspirin intolerance · score 0.04
- Familial ocular anterior segment mesenchymal dysgenesis · score 0.04
- exfoliation syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2X8-F1 | alphafold | PREDICTED | 55.11 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2X8.
Amino-acid sequence (130 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with IFI27L2?
The strongest Open Targets associations for IFI27L2 are metabolite measurement, retinitis pigmentosa, Familial exudative vitreoretinopathy, snowflake vitreoretinal degeneration and Coats disease.
How long is the IFI27L2 protein?
The Homo sapiens IFI27L2 protein (UniProt Q9H2X8) is 130 amino acids long.
Browse: Targets: I · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2X8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2X8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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