Solute carrier family 12 member 5 (SLC12A5)
Homo sapiens — UniProt Q9H2X9
Data last refreshed: (UniProt release unknown)
Key facts
Solute carrier family 12 member 5 (SLC12A5) is a protein from Homo sapiens identified by UniProt accession Q9H2X9, 1139 residues long. MolForge cross-references it against 0 known binders and 274 disease associations.
- UniProt accession: Q9H2X9; gene symbol SLC12A5.
- Organism: Homo sapiens.
- Length: 1139 amino acids.
- Top disease associations (Open Targets): malignant migrating partial seizures of infancy, generalised epilepsy and developmental and epileptic encephalopathy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Solute carrier family 12 member 5 |
|---|---|
| UniProt accession | Q9H2X9 |
| Gene | SLC12A5 |
| Organism | Homo sapiens |
| Length | 1139 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (274)
Diseases linked to this target (Open Targets).
- malignant migrating partial seizures of infancy · score 0.66
- generalised epilepsy · score 0.63
- developmental and epileptic encephalopathy · score 0.56
- Febrile seizure (within the age range of 3 months to 6 years) · score 0.37
- epilepsy of infancy with migrating focal seizures · score 0.37
- neurodegenerative disease · score 0.35
- wellbeing measurement · score 0.26
- alkaline phosphatase measurement · score 0.24
- chronotype measurement · score 0.23
- risk-taking behaviour · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2X9-F1 | alphafold | PREDICTED | 78.46 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2X9.
Amino-acid sequence (1139 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SLC12A5?
The strongest Open Targets associations for SLC12A5 are malignant migrating partial seizures of infancy, generalised epilepsy, developmental and epileptic encephalopathy, Febrile seizure (within the age range of 3 months to 6 years) and epilepsy of infancy with migrating focal seizures.
How long is the SLC12A5 protein?
The Homo sapiens SLC12A5 protein (UniProt Q9H2X9) is 1139 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2X9 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2X9 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.