Homeobox protein Nkx-2.4 (NKX2-4)
Homo sapiens — UniProt Q9H2Z4
Data last refreshed: (UniProt release unknown)
Key facts
Homeobox protein Nkx-2.4 (NKX2-4) is a protein from Homo sapiens identified by UniProt accession Q9H2Z4, 354 residues long. MolForge cross-references it against 0 known binders and 40 disease associations.
- UniProt accession: Q9H2Z4; gene symbol NKX2-4.
- Organism: Homo sapiens.
- Length: 354 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, body mass index and erythrocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Homeobox protein Nkx-2.4 |
|---|---|
| UniProt accession | Q9H2Z4 |
| Gene | NKX2-4 |
| Organism | Homo sapiens |
| Length | 354 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (40)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.37
- body mass index · score 0.29
- erythrocyte count · score 0.21
- body height · score 0.21
- Red cell distribution width · score 0.15
- mean corpuscular volume · score 0.15
- mean corpuscular hemoglobin concentration · score 0.12
- autism spectrum disorder · score 0.11
- mean corpuscular hemoglobin · score 0.11
- unipolar depression · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H2Z4-F1 | alphafold | PREDICTED | 57.30 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H2Z4.
Amino-acid sequence (354 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NKX2-4?
The strongest Open Targets associations for NKX2-4 are neurodegenerative disease, body mass index, erythrocyte count, body height and Red cell distribution width.
How long is the NKX2-4 protein?
The Homo sapiens NKX2-4 protein (UniProt Q9H2Z4) is 354 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H2Z4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H2Z4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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