Protein tweety homolog 1 (TTYH1)

About Protein tweety homolog 1

Protein tweety homolog 1 (TTYH1) is a protein from Homo sapiens identified by UniProt accession Q9H313, 450 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	Protein tweety homolog 1
UniProt accession	Q9H313
Gene	TTYH1
Organism	Homo sapiens
Length	450 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

idiopathic pulmonary fibrosis · score 0.23
lymphocyte count · score 0.18
glioblastoma multiforme · score 0.18
breast adenocarcinoma · score 0.16
head and neck squamous cell carcinoma · score 0.12
self reported educational attainment · score 0.11
drug use measurement · score 0.06
cancer · score 0.04
breast carcinoma · score 0.04
medulloblastoma · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9H313-F1	alphafold	PREDICTED	89.65	—

Amino-acid sequence (450 residues)

MGAPPGYRPS AWVHLLHQLP RADFQLRPVP SVFAPQEQEY QQALLLVAAL AGLGLGLSLI FIAVYLIRFC CCRPPEPPGS KIPSPGGGCV TWSCIVALLA GCTGIGIGFY GNSETSDGVS QLSSALLHAN HTLSTIDHLV LETVERLGEA VRTELTTLEE VLEPRTELVA AARGARRQAE AAAQQLQGLA FWQGVPLSPL QVAENVSFVE EYRWLAYVLL LLLELLVCLF TLLGLAKQSK WLVIVMTVMS LLVLVLSWGS MGLEAATAVG LSDFCSNPDP YVLNLTQEET GLSSDILSYY LLCNRAVSNP FQQRLTLSQR ALANIHSQLL GLEREAVPQF PSAQKPLLSL EETLNVTEGN FHQLVALLHC RSLHKDYGAA LRGLCEDALE GLLFLLLFSL LSAGALATAL CSLPRAWALF PPSDDYDDTD DDDPFNPQES KRFVQWQSSI

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards