A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10)
Homo sapiens — UniProt Q9H324
Data last refreshed: (UniProt release unknown)
Key facts
A disintegrin and metalloproteinase with thrombospondin motifs 10 (ADAMTS10) is a protein from Homo sapiens identified by UniProt accession Q9H324, 1103 residues long. MolForge cross-references it against 0 known binders and 106 disease associations.
- UniProt accession: Q9H324; gene symbol ADAMTS10.
- Organism: Homo sapiens.
- Length: 1103 amino acids.
- Top disease associations (Open Targets): body height, Weill-Marchesani syndrome and forced expiratory volume.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | A disintegrin and metalloproteinase with thrombospondin motifs 10 |
|---|---|
| UniProt accession | Q9H324 |
| Gene | ADAMTS10 |
| Organism | Homo sapiens |
| Length | 1103 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (106)
Diseases linked to this target (Open Targets).
- body height · score 0.69
- Weill-Marchesani syndrome · score 0.66
- forced expiratory volume · score 0.62
- vital capacity · score 0.47
- fat body mass · score 0.47
- lean body mass · score 0.44
- BMI-adjusted waist circumference · score 0.42
- body weights and measures · score 0.42
- body fat distribution · score 0.41
- body weight · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H324-F1 | alphafold | PREDICTED | 73.72 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H324.
Amino-acid sequence (1103 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with ADAMTS10?
The strongest Open Targets associations for ADAMTS10 are body height, Weill-Marchesani syndrome, forced expiratory volume, vital capacity and fat body mass.
How long is the ADAMTS10 protein?
The Homo sapiens ADAMTS10 protein (UniProt Q9H324) is 1103 amino acids long.
Browse: Targets: A · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H324 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H324 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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