Tumor protein 63 (TP63)
Homo sapiens — UniProt Q9H3D4
Data last refreshed: (UniProt release unknown)
Key facts
Tumor protein 63 (TP63) is a protein from Homo sapiens identified by UniProt accession Q9H3D4, 680 residues long. MolForge cross-references it against 0 known binders and 831 disease associations.
- UniProt accession: Q9H3D4; gene symbol TP63.
- Organism: Homo sapiens.
- Length: 680 amino acids.
- Top disease associations (Open Targets): ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3, Ankyloblepharon - ectodermal defects - cleft lip/palate and Split hand-split foot malformation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Tumor protein 63 |
|---|---|
| UniProt accession | Q9H3D4 |
| Gene | TP63 |
| Organism | Homo sapiens |
| Length | 680 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (831)
Diseases linked to this target (Open Targets).
- ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3 · score 0.84
- Ankyloblepharon - ectodermal defects - cleft lip/palate · score 0.83
- Split hand-split foot malformation · score 0.79
- limb-mammary syndrome · score 0.78
- ADULT syndrome · score 0.77
- ankyloblepharon-ectodermal defects-cleft lip/palate syndrome · score 0.72
- split hand-foot malformation 4 · score 0.71
- orofacial cleft 8 · score 0.67
- EEC syndrome · score 0.65
- lung adenocarcinoma · score 0.58
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3D4-F1 | alphafold | PREDICTED | 63.19 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3D4.
Amino-acid sequence (680 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TP63?
The strongest Open Targets associations for TP63 are ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 3, Ankyloblepharon - ectodermal defects - cleft lip/palate, Split hand-split foot malformation, limb-mammary syndrome and ADULT syndrome.
How long is the TP63 protein?
The Homo sapiens TP63 protein (UniProt Q9H3D4) is 680 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3D4 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3D4 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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