Sorting nexin-25 (SNX25)
Homo sapiens — UniProt Q9H3E2
Data last refreshed: (UniProt release unknown)
Key facts
Sorting nexin-25 (SNX25) is a protein from Homo sapiens identified by UniProt accession Q9H3E2, 840 residues long. MolForge cross-references it against 0 known binders and 28 disease associations.
- UniProt accession: Q9H3E2; gene symbol SNX25.
- Organism: Homo sapiens.
- Length: 840 amino acids.
- Top disease associations (Open Targets): attention deficit hyperactivity disorder, Tourette syndrome and attention deficit-hyperactivity disorder 8.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Sorting nexin-25 |
|---|---|
| UniProt accession | Q9H3E2 |
| Gene | SNX25 |
| Organism | Homo sapiens |
| Length | 840 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (28)
Diseases linked to this target (Open Targets).
- attention deficit hyperactivity disorder · score 0.06
- Tourette syndrome · score 0.05
- attention deficit-hyperactivity disorder 8 · score 0.05
- schizophrenia 15 · score 0.05
- Phelan-McDermid syndrome · score 0.04
- 8p23.1 microdeletion syndrome · score 0.04
- Potocki-Lupski syndrome · score 0.03
- X-linked non-syndromic intellectual disability · score 0.03
- X-linked dominant intellectual disability - epilepsy syndrome · score 0.03
- temporal lobe epilepsy · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3E2-F1 | alphafold | PREDICTED | 75.60 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3E2.
Amino-acid sequence (840 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SNX25?
The strongest Open Targets associations for SNX25 are attention deficit hyperactivity disorder, Tourette syndrome, attention deficit-hyperactivity disorder 8, schizophrenia 15 and Phelan-McDermid syndrome.
How long is the SNX25 protein?
The Homo sapiens SNX25 protein (UniProt Q9H3E2) is 840 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3E2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3E2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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