BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10)
Homo sapiens — UniProt Q9H3F6
Data last refreshed: (UniProt release unknown)
Key facts
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 (KCTD10) is a protein from Homo sapiens identified by UniProt accession Q9H3F6, 313 residues long. MolForge cross-references it against 0 known binders and 102 disease associations.
- UniProt accession: Q9H3F6; gene symbol KCTD10.
- Organism: Homo sapiens.
- Length: 313 amino acids.
- Top disease associations (Open Targets): high density lipoprotein cholesterol measurement, total cholesterol measurement and monocyte count.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3 |
|---|---|
| UniProt accession | Q9H3F6 |
| Gene | KCTD10 |
| Organism | Homo sapiens |
| Length | 313 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (102)
Diseases linked to this target (Open Targets).
- high density lipoprotein cholesterol measurement · score 0.27
- total cholesterol measurement · score 0.19
- monocyte count · score 0.19
- body mass index · score 0.18
- Red cell distribution width · score 0.18
- insomnia measurement · score 0.18
- coronary artery disease · score 0.18
- sleep duration · score 0.15
- apolipoprotein A 1 measurement · score 0.15
- protein measurement · score 0.14
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3F6-F1 | alphafold | PREDICTED | 82.23 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3F6.
Amino-acid sequence (313 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCTD10?
The strongest Open Targets associations for KCTD10 are high density lipoprotein cholesterol measurement, total cholesterol measurement, monocyte count, body mass index and Red cell distribution width.
How long is the KCTD10 protein?
The Homo sapiens KCTD10 protein (UniProt Q9H3F6) is 313 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3F6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3F6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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