tRNA dimethylallyltransferase (TRIT1)
Homo sapiens — UniProt Q9H3H1
Data last refreshed: (UniProt release unknown)
Key facts
tRNA dimethylallyltransferase (TRIT1) is a protein from Homo sapiens identified by UniProt accession Q9H3H1, 467 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q9H3H1; gene symbol TRIT1.
- Organism: Homo sapiens.
- Length: 467 amino acids.
- Top disease associations (Open Targets): combined oxidative phosphorylation deficiency 35, neurodegenerative disease and genetic disorder.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | tRNA dimethylallyltransferase |
|---|---|
| UniProt accession | Q9H3H1 |
| Gene | TRIT1 |
| Organism | Homo sapiens |
| Length | 467 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation deficiency 35 · score 0.80
- neurodegenerative disease · score 0.51
- genetic disorder · score 0.50
- mitochondrial disease · score 0.37
- Epileptic encephalopathy · score 0.27
- Macrocephaly · score 0.27
- IGF-1 measurement · score 0.23
- FEV/FVC ratio · score 0.22
- balding measurement · score 0.19
- leukocyte count · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3H1-F1 | alphafold | PREDICTED | 84.53 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3H1.
Amino-acid sequence (467 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TRIT1?
The strongest Open Targets associations for TRIT1 are combined oxidative phosphorylation deficiency 35, neurodegenerative disease, genetic disorder, mitochondrial disease and Epileptic encephalopathy.
How long is the TRIT1 protein?
The Homo sapiens TRIT1 protein (UniProt Q9H3H1) is 467 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3H1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3H1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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