UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1)
Homo sapiens — UniProt Q9H3H5
Data last refreshed: (UniProt release unknown)
Key facts
UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1) is a protein from Homo sapiens identified by UniProt accession Q9H3H5, 408 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.
- UniProt accession: Q9H3H5; gene symbol DPAGT1.
- Organism: Homo sapiens.
- Length: 408 amino acids.
- Top disease associations (Open Targets): Congenital myasthenic syndromes, DPAGT1-congenital disorder of glycosylation and congenital disorder of glycosylation.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase |
|---|---|
| UniProt accession | Q9H3H5 |
| Gene | DPAGT1 |
| Organism | Homo sapiens |
| Length | 408 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (95)
Diseases linked to this target (Open Targets).
- Congenital myasthenic syndromes · score 0.80
- DPAGT1-congenital disorder of glycosylation · score 0.80
- congenital disorder of glycosylation · score 0.55
- neurodegenerative disease · score 0.52
- genetic disorder · score 0.44
- congenital disorder of glycosylation type I · score 0.37
- congenital myasthenic syndromes with glycosylation defect · score 0.37
- Abnormality of metabolism/homeostasis · score 0.27
- mean corpuscular volume · score 0.21
- mean reticulocyte volume · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3H5-F1 | alphafold | PREDICTED | 94.68 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3H5.
Amino-acid sequence (408 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with DPAGT1?
The strongest Open Targets associations for DPAGT1 are Congenital myasthenic syndromes, DPAGT1-congenital disorder of glycosylation, congenital disorder of glycosylation, neurodegenerative disease and genetic disorder.
How long is the DPAGT1 protein?
The Homo sapiens DPAGT1 protein (UniProt Q9H3H5) is 408 amino acids long.
Browse: Targets: D · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3H5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3H5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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