Mitochondrial translation release factor in rescue (MTRFR)
Homo sapiens — UniProt Q9H3J6
Data last refreshed: (UniProt release unknown)
Key facts
Mitochondrial translation release factor in rescue (MTRFR) is a protein from Homo sapiens identified by UniProt accession Q9H3J6, 166 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.
- UniProt accession: Q9H3J6; gene symbol MTRFR.
- Organism: Homo sapiens.
- Length: 166 amino acids.
- Top disease associations (Open Targets): combined oxidative phosphorylation defect type 7, Autosomal recessive spastic paraplegia type 55 and hereditary spastic paraplegia 55.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Mitochondrial translation release factor in rescue |
|---|---|
| UniProt accession | Q9H3J6 |
| Gene | MTRFR |
| Organism | Homo sapiens |
| Length | 166 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (117)
Diseases linked to this target (Open Targets).
- combined oxidative phosphorylation defect type 7 · score 0.73
- Autosomal recessive spastic paraplegia type 55 · score 0.65
- hereditary spastic paraplegia 55 · score 0.61
- Spastic paraplegia · score 0.53
- Leigh syndrome · score 0.37
- Cranio-cervical dystonia with laryngeal and upper-limb involvement · score 0.37
- Neurodevelopmental disorder · score 0.34
- self reported educational attainment · score 0.30
- hereditary motor and sensory neuropathy type 6 · score 0.27
- Abnormal brain morphology · score 0.27
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3J6-F1 | alphafold | PREDICTED | 83.26 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3J6.
Amino-acid sequence (166 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with MTRFR?
The strongest Open Targets associations for MTRFR are combined oxidative phosphorylation defect type 7, Autosomal recessive spastic paraplegia type 55, hereditary spastic paraplegia 55, Spastic paraplegia and Leigh syndrome.
How long is the MTRFR protein?
The Homo sapiens MTRFR protein (UniProt Q9H3J6) is 166 amino acids long.
Browse: Targets: M · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3J6 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3J6 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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