Growth hormone-inducible transmembrane protein (GHITM)
Homo sapiens — UniProt Q9H3K2
Data last refreshed: (UniProt release unknown)
Key facts
Growth hormone-inducible transmembrane protein (GHITM) is a protein from Homo sapiens identified by UniProt accession Q9H3K2, 345 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q9H3K2; gene symbol GHITM.
- Organism: Homo sapiens.
- Length: 345 amino acids.
- Top disease associations (Open Targets): melanocytic nevus, influenza A (H1N1) and neurofibrillary tangles measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Growth hormone-inducible transmembrane protein |
|---|---|
| UniProt accession | Q9H3K2 |
| Gene | GHITM |
| Organism | Homo sapiens |
| Length | 345 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- melanocytic nevus · score 0.22
- influenza A (H1N1) · score 0.12
- neurofibrillary tangles measurement · score 0.10
- allergic rhinitis · score 0.05
- autosomal dominant mitochondrial myopathy with exercise intolerance · score 0.05
- serum metabolite measurement · score 0.05
- combined oxidative phosphorylation deficiency 49 · score 0.04
- autosomal recessive limb-girdle muscular dystrophy type 2L · score 0.04
- autosomal dominant distal myopathy · score 0.04
- Distal myopathy, Nonaka type · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3K2-F1 | alphafold | PREDICTED | 77.64 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3K2.
Amino-acid sequence (345 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with GHITM?
The strongest Open Targets associations for GHITM are melanocytic nevus, influenza A (H1N1), neurofibrillary tangles measurement, allergic rhinitis and autosomal dominant mitochondrial myopathy with exercise intolerance.
How long is the GHITM protein?
The Homo sapiens GHITM protein (UniProt Q9H3K2) is 345 amino acids long.
Browse: Targets: G · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3K2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3K2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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