Voltage-gated potassium channel regulatory subunit KCNF1 (KCNF1)
Homo sapiens — UniProt Q9H3M0
Data last refreshed: (UniProt release unknown)
Key facts
Voltage-gated potassium channel regulatory subunit KCNF1 (KCNF1) is a protein from Homo sapiens identified by UniProt accession Q9H3M0, 494 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.
- UniProt accession: Q9H3M0; gene symbol KCNF1.
- Organism: Homo sapiens.
- Length: 494 amino acids.
- Top disease associations (Open Targets): multiple sclerosis, Myasthenia gravis and small cell carcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Voltage-gated potassium channel regulatory subunit KCNF1 |
|---|---|
| UniProt accession | Q9H3M0 |
| Gene | KCNF1 |
| Organism | Homo sapiens |
| Length | 494 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (85)
Diseases linked to this target (Open Targets).
- multiple sclerosis · score 0.59
- Myasthenia gravis · score 0.57
- small cell carcinoma · score 0.46
- Muscle weakness · score 0.46
- secondary progressive multiple sclerosis · score 0.43
- anterior ischemic optic neuropathy · score 0.37
- primary progressive multiple sclerosis · score 0.37
- transverse myelitis · score 0.37
- atrial flutter · score 0.35
- atrial fibrillation · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3M0-F1 | alphafold | PREDICTED | 79.63 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3M0.
Amino-acid sequence (494 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with KCNF1?
The strongest Open Targets associations for KCNF1 are multiple sclerosis, Myasthenia gravis, small cell carcinoma, Muscle weakness and secondary progressive multiple sclerosis.
How long is the KCNF1 protein?
The Homo sapiens KCNF1 protein (UniProt Q9H3M0) is 494 amino acids long.
Browse: Targets: K · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3M0 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3M0 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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