Thioredoxin-interacting protein (TXNIP)
Homo sapiens — UniProt Q9H3M7
Data last refreshed: (UniProt release unknown)
Key facts
Thioredoxin-interacting protein (TXNIP) is a protein from Homo sapiens identified by UniProt accession Q9H3M7, 391 residues long. MolForge cross-references it against 0 known binders and 628 disease associations.
- UniProt accession: Q9H3M7; gene symbol TXNIP.
- Organism: Homo sapiens.
- Length: 391 amino acids.
- Top disease associations (Open Targets): lung adenocarcinoma, ovarian cancer and neoplasm.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Thioredoxin-interacting protein |
|---|---|
| UniProt accession | Q9H3M7 |
| Gene | TXNIP |
| Organism | Homo sapiens |
| Length | 391 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (628)
Diseases linked to this target (Open Targets).
- lung adenocarcinoma · score 0.23
- ovarian cancer · score 0.18
- neoplasm · score 0.11
- hepatocellular carcinoma · score 0.10
- cutaneous melanoma · score 0.10
- diabetic nephropathy · score 0.10
- acute myeloid leukemia · score 0.10
- cancer · score 0.10
- non-alcoholic steatohepatitis · score 0.10
- subarachnoid hemorrhage · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3M7-F1 | alphafold | PREDICTED | 78.70 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3M7.
Amino-acid sequence (391 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TXNIP?
The strongest Open Targets associations for TXNIP are lung adenocarcinoma, ovarian cancer, neoplasm, hepatocellular carcinoma and cutaneous melanoma.
How long is the TXNIP protein?
The Homo sapiens TXNIP protein (UniProt Q9H3M7) is 391 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3M7 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3M7 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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