Thioredoxin-related transmembrane protein 1 (TMX1)
Homo sapiens — UniProt Q9H3N1
Data last refreshed: (UniProt release unknown)
Key facts
Thioredoxin-related transmembrane protein 1 (TMX1) is a protein from Homo sapiens identified by UniProt accession Q9H3N1, 280 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.
- UniProt accession: Q9H3N1; gene symbol TMX1.
- Organism: Homo sapiens.
- Length: 280 amino acids.
- Top disease associations (Open Targets): adolescent idiopathic scoliosis, Cleft palate and cleft lip.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Thioredoxin-related transmembrane protein 1 |
|---|---|
| UniProt accession | Q9H3N1 |
| Gene | TMX1 |
| Organism | Homo sapiens |
| Length | 280 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (39)
Diseases linked to this target (Open Targets).
- adolescent idiopathic scoliosis · score 0.24
- Cleft palate · score 0.22
- cleft lip · score 0.22
- cancer · score 0.08
- melanoma · score 0.08
- neoplasm · score 0.06
- hepatocellular carcinoma · score 0.01
- viral disease · score 0.01
- bacteriemia · score 0.01
- breast cancer · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3N1-F1 | alphafold | PREDICTED | 76.61 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3N1.
Amino-acid sequence (280 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMX1?
The strongest Open Targets associations for TMX1 are adolescent idiopathic scoliosis, Cleft palate, cleft lip, cancer and melanoma.
How long is the TMX1 protein?
The Homo sapiens TMX1 protein (UniProt Q9H3N1) is 280 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3N1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3N1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.