Histamine H4 receptor (HRH4)
Homo sapiens — UniProt Q9H3N8
Data last refreshed: (UniProt release unknown)
Key facts
Histamine H4 receptor (HRH4) is a protein from Homo sapiens identified by UniProt accession Q9H3N8, 390 residues long. MolForge cross-references it against 26 known binders and 230 disease associations.
- UniProt accession: Q9H3N8; gene symbol HRH4.
- Organism: Homo sapiens.
- Length: 390 amino acids.
- Top disease associations (Open Targets): body mass index, body fat percentage and lean body mass.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Histamine H4 receptor |
|---|---|
| UniProt accession | Q9H3N8 |
| Gene | HRH4 |
| Organism | Homo sapiens |
| Length | 390 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (230)
Diseases linked to this target (Open Targets).
- body mass index · score 0.35
- body fat percentage · score 0.34
- lean body mass · score 0.31
- vital capacity · score 0.31
- neurodegenerative disease · score 0.29
- forced expiratory volume · score 0.29
- self reported educational attainment · score 0.24
- visceral adipose tissue measurement · score 0.24
- body height · score 0.23
- ovarian cancer · score 0.23
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3N8-F1 | alphafold | PREDICTED | 76.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3N8.
Amino-acid sequence (390 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with HRH4?
The strongest Open Targets associations for HRH4 are body mass index, body fat percentage, lean body mass, vital capacity and neurodegenerative disease.
How long is the HRH4 protein?
The Homo sapiens HRH4 protein (UniProt Q9H3N8) is 390 amino acids long.
Browse: Targets: H · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3N8 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3N8 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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