Negative elongation factor A (NELFA)
Homo sapiens — UniProt Q9H3P2
Data last refreshed: (UniProt release unknown)
Key facts
Negative elongation factor A (NELFA) is a protein from Homo sapiens identified by UniProt accession Q9H3P2, 528 residues long. MolForge cross-references it against 0 known binders and 64 disease associations.
- UniProt accession: Q9H3P2; gene symbol NELFA.
- Organism: Homo sapiens.
- Length: 528 amino acids.
- Top disease associations (Open Targets): HIV infection, breast carcinoma and breast adenocarcinoma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Negative elongation factor A |
|---|---|
| UniProt accession | Q9H3P2 |
| Gene | NELFA |
| Organism | Homo sapiens |
| Length | 528 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (64)
Diseases linked to this target (Open Targets).
- HIV infection · score 0.59
- breast carcinoma · score 0.27
- breast adenocarcinoma · score 0.23
- head and neck squamous cell carcinoma · score 0.18
- squamous cell lung carcinoma · score 0.18
- ovarian cancer · score 0.18
- endometrial cancer · score 0.18
- lung adenocarcinoma · score 0.18
- esophageal cancer · score 0.16
- urinary bladder cancer · score 0.12
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3P2-F1 | alphafold | PREDICTED | 68.47 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3P2.
Amino-acid sequence (528 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NELFA?
The strongest Open Targets associations for NELFA are HIV infection, breast carcinoma, breast adenocarcinoma, head and neck squamous cell carcinoma and squamous cell lung carcinoma.
How long is the NELFA protein?
The Homo sapiens NELFA protein (UniProt Q9H3P2) is 528 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3P2 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3P2 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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