Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (NDST4)
Homo sapiens — UniProt Q9H3R1
Data last refreshed: (UniProt release unknown)
Key facts
Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 (NDST4) is a protein from Homo sapiens identified by UniProt accession Q9H3R1, 872 residues long. MolForge cross-references it against 0 known binders and 47 disease associations.
- UniProt accession: Q9H3R1; gene symbol NDST4.
- Organism: Homo sapiens.
- Length: 872 amino acids.
- Top disease associations (Open Targets): mathematical ability, age at menarche and metabolite measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 4 |
|---|---|
| UniProt accession | Q9H3R1 |
| Gene | NDST4 |
| Organism | Homo sapiens |
| Length | 872 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (47)
Diseases linked to this target (Open Targets).
- mathematical ability · score 0.43
- age at menarche · score 0.32
- metabolite measurement · score 0.30
- resistin measurement · score 0.22
- colorectal carcinoma · score 0.06
- Hirschsprung disease · score 0.05
- chronic intestinal pseudoobstruction · score 0.05
- AXIN2-related attenuated familial adenomatous polyposis · score 0.04
- colorectal cancer, susceptibility to, 3 · score 0.04
- Lynch syndrome · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3R1-F1 | alphafold | PREDICTED | 91.04 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3R1.
Amino-acid sequence (872 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with NDST4?
The strongest Open Targets associations for NDST4 are mathematical ability, age at menarche, metabolite measurement, resistin measurement and colorectal carcinoma.
How long is the NDST4 protein?
The Homo sapiens NDST4 protein (UniProt Q9H3R1) is 872 amino acids long.
Browse: Targets: N · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3R1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3R1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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