Centromere protein H (CENPH)
Homo sapiens — UniProt Q9H3R5
Data last refreshed: (UniProt release unknown)
Key facts
Centromere protein H (CENPH) is a protein from Homo sapiens identified by UniProt accession Q9H3R5, 247 residues long. MolForge cross-references it against 0 known binders and 73 disease associations.
- UniProt accession: Q9H3R5; gene symbol CENPH.
- Organism: Homo sapiens.
- Length: 247 amino acids.
- Top disease associations (Open Targets): neurodegenerative disease, reticulocyte measurement and systolic blood pressure.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Centromere protein H |
|---|---|
| UniProt accession | Q9H3R5 |
| Gene | CENPH |
| Organism | Homo sapiens |
| Length | 247 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (73)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- reticulocyte measurement · score 0.10
- systolic blood pressure · score 0.09
- vital capacity · score 0.08
- creatinine measurement · score 0.08
- esophageal carcinoma · score 0.08
- neutrophil percentage of leukocytes · score 0.07
- cystatin C measurement · score 0.06
- glomerular filtration rate · score 0.06
- neoplasm · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3R5-F1 | alphafold | PREDICTED | 81.78 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3R5.
Amino-acid sequence (247 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with CENPH?
The strongest Open Targets associations for CENPH are neurodegenerative disease, reticulocyte measurement, systolic blood pressure, vital capacity and creatinine measurement.
How long is the CENPH protein?
The Homo sapiens CENPH protein (UniProt Q9H3R5) is 247 amino acids long.
Browse: Targets: C · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3R5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3R5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
For research and educational use only — not medical advice. This page is compiled automatically from public databases. It is not written or reviewed by a clinician. Do not start, stop or change any treatment based on it; consult a qualified healthcare professional. Spotted an error? See our corrections policy or email hello@molforge.ai.