Semaphorin-4A (SEMA4A)
Homo sapiens — UniProt Q9H3S1
Data last refreshed: (UniProt release unknown)
Key facts
Semaphorin-4A (SEMA4A) is a protein from Homo sapiens identified by UniProt accession Q9H3S1, 761 residues long. MolForge cross-references it against 0 known binders and 251 disease associations.
- UniProt accession: Q9H3S1; gene symbol SEMA4A.
- Organism: Homo sapiens.
- Length: 761 amino acids.
- Top disease associations (Open Targets): Cone rod dystrophy, retinitis pigmentosa and Retinal dystrophy.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Semaphorin-4A |
|---|---|
| UniProt accession | Q9H3S1 |
| Gene | SEMA4A |
| Organism | Homo sapiens |
| Length | 761 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (251)
Diseases linked to this target (Open Targets).
- Cone rod dystrophy · score 0.65
- retinitis pigmentosa · score 0.62
- Retinal dystrophy · score 0.37
- helicoid peripapillary chorioretinal degeneration · score 0.34
- leukocyte count · score 0.32
- neutrophil count · score 0.28
- monocyte count · score 0.27
- Posterior column ataxia - retinitis pigmentosa · score 0.24
- systolic blood pressure · score 0.21
- body height · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3S1-F1 | alphafold | PREDICTED | 84.34 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3S1.
Amino-acid sequence (761 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with SEMA4A?
The strongest Open Targets associations for SEMA4A are Cone rod dystrophy, retinitis pigmentosa, Retinal dystrophy, helicoid peripapillary chorioretinal degeneration and leukocyte count.
How long is the SEMA4A protein?
The Homo sapiens SEMA4A protein (UniProt Q9H3S1) is 761 amino acids long.
Browse: Targets: S · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3S1 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3S1 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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