Transmembrane protease serine 5 (TMPRSS5)
Homo sapiens — UniProt Q9H3S3
Data last refreshed: (UniProt release unknown)
Key facts
Transmembrane protease serine 5 (TMPRSS5) is a protein from Homo sapiens identified by UniProt accession Q9H3S3, 457 residues long. MolForge cross-references it against 0 known binders and 56 disease associations.
- UniProt accession: Q9H3S3; gene symbol TMPRSS5.
- Organism: Homo sapiens.
- Length: 457 amino acids.
- Top disease associations (Open Targets): low density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement and bilirubin measurement.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | Transmembrane protease serine 5 |
|---|---|
| UniProt accession | Q9H3S3 |
| Gene | TMPRSS5 |
| Organism | Homo sapiens |
| Length | 457 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (56)
Diseases linked to this target (Open Targets).
- low density lipoprotein cholesterol measurement · score 0.37
- sex hormone-binding globulin measurement · score 0.35
- bilirubin measurement · score 0.30
- blood protein measurement · score 0.30
- Age-related nuclear cataract · score 0.25
- PHF-tau measurement · score 0.24
- serum non-albumin protein measurement · score 0.21
- chronic lymphocytic leukemia · score 0.20
- unipolar depression · score 0.19
- alcohol use disorder measurement · score 0.17
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3S3-F1 | alphafold | PREDICTED | 79.33 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3S3.
Amino-acid sequence (457 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with TMPRSS5?
The strongest Open Targets associations for TMPRSS5 are low density lipoprotein cholesterol measurement, sex hormone-binding globulin measurement, bilirubin measurement, blood protein measurement and Age-related nuclear cataract.
How long is the TMPRSS5 protein?
The Homo sapiens TMPRSS5 protein (UniProt Q9H3S3) is 457 amino acids long.
Browse: Targets: T · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3S3 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3S3 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
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