GPI alpha-1,4-mannosyltransferase I, catalytic subunit (PIGM)
Homo sapiens — UniProt Q9H3S5
Data last refreshed: (UniProt release unknown)
Key facts
GPI alpha-1,4-mannosyltransferase I, catalytic subunit (PIGM) is a protein from Homo sapiens identified by UniProt accession Q9H3S5, 423 residues long. MolForge cross-references it against 0 known binders and 26 disease associations.
- UniProt accession: Q9H3S5; gene symbol PIGM.
- Organism: Homo sapiens.
- Length: 423 amino acids.
- Top disease associations (Open Targets): hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency, genetic disorder and multiple myeloma.
- 3D structure: AlphaFold model available.
Target properties
| Protein name | GPI alpha-1,4-mannosyltransferase I, catalytic subunit |
|---|---|
| UniProt accession | Q9H3S5 |
| Gene | PIGM |
| Organism | Homo sapiens |
| Length | 423 residues |
| Molecular weight | — |
| EC numbers | — |
| Target class | — |
| Subcellular location | — |
| Keywords | — |
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|---|
| Druggability score | — |
| Pocket score | — |
| Max clinical phase | — |
Disease associations (26)
Diseases linked to this target (Open Targets).
- hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency · score 0.68
- genetic disorder · score 0.27
- multiple myeloma · score 0.03
- cancer · score 0.01
- infection · score 0.01
- infect · score 0.01
- thrombotic disease · score 0.01
- lung adenocarcinoma · score 0.01
- paroxysmal nocturnal hemoglobinuria · score 0.00
- hepatocellular carcinoma · score 0.00
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|---|---|---|---|
| AF-Q9H3S5-F1 | alphafold | PREDICTED | 90.35 | — |
Experimental structures are not indexed in MolForge yet — search RCSB PDB for Q9H3S5.
Amino-acid sequence (423 residues)
Frequently asked questions
Answers are generated from the structured data on this page, not written by hand.
Which diseases are associated with PIGM?
The strongest Open Targets associations for PIGM are hypercoagulability syndrome due to glycosylphosphatidylinositol deficiency, genetic disorder, multiple myeloma, cancer and infection.
How long is the PIGM protein?
The Homo sapiens PIGM protein (UniProt Q9H3S5) is 423 amino acids long.
Browse: Targets: P · all protein targets A–Z · drugs A–Z.
Sources
- UniProtKB Q9H3S5 — name, gene, function, sequence, keywords (CC BY 4.0)
- AlphaFold DB Q9H3S5 — predicted 3D structure (CC BY 4.0)
- Open Targets Platform — disease associations and tractability (CC0)
How this page is built: methodology · editorial policy & corrections.
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